Journal: Scientific Reports
Article Title: A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective
doi: 10.1038/s41598-024-76163-w
Figure Lengend Snippet: Lung histopathological analysis of immunized B6.Cg-Tg(K18-ACE2)2Prlmn animals challenged with SARS-CoV-2. (A-C) Lung of non-infected animals. (A) Panoramic lung vision. (B) Lung parenchyma with normal appearance. (C) Type I and II pneumocytes with normal morphology (arrow black PI and arrow black PII). (D-I) Lung of the infected controls animals previously immunized with PBS, RBD, and QβVLPs. (D) Panoramic lung vision. (E) Perivascular inflammation (asterisk). (F) Alveolar fibrin and hemorrhage (blue F and yellow H arrows, respectively). (G) Syncytial and single cell necrosis (green N arrow). (H) Type II pneumocyte hyperplasia (gray PII arrows). (I) Macrophages (pink M arrows). (J-L) Lung os the infected controls animals previously immunized with QβVLPs-RBD vaccine (20 µg). (J) Panoramic lung vision. (K) Type II pneumocyte hyperplasia (gray PII arrows). (L) Alveolar fibrin (blue F arrow). (M-O) Lung os the infected controls animals previously immunized with QβVLPs-RBD vaccine (50 µg). (M) Panoramic lung vision. (N) Lung parenchyma with normal appearance. (O) Type I and II pneumocytes with normal morphology (arrow black PI and arrow black PII). The 4 μm thick sections were stained with hematoxylin and eosin and images were captured with Slide Digitizer − 3D Histech scanner and analyzed in Download CaseViewer 2.4, 64-bit version (3D- Histotech, Hungary - https://www.3dhistech.com/solutions/caseviewer/ ).
Article Snippet: The 4 μm thick sections were stained with hematoxylin and eosin and images were captured with Slide Digitizer − 3D Histech scanner and analyzed in Download CaseViewer 2.4, 64-bit version (3D- Histotech, Hungary - https://www.3dhistech.com/solutions/caseviewer/ ).
Techniques: Infection, Staining